Mark Lamotte, our Senior Leader Health Economic and the founder of Th(is)²Modeling, brings a rich and diverse background to our team. With a medical doctor degree specialized in cardiology, Mark`s journey began with six years of clinical practice in both invasive and non-invasive cardiology.

Mark then joined Rhône-Poulenc Rorer, where he served as a Cardiovascular Medical Advisor focusing on antithrombosis. In January 2000, he stepped into the world of health economics by joining HEDM, which later became part of IQVIA in May 2004. During his tenure at IQVIA, Mark wore multiple hats, excelling as a Modeler, Project Manager, and Scientific Director. By 2008, Mark was leading the Belgian HEOR team. In 2016, Mark`s role expanded into leading Health Economics and Market Access developments across the European region. Within 2 years, Mark became the Global Leader of Health Economic Modeling in IQVIA. Notably, Mark Lamotte spearheaded the development of the Core Diabetes Model, a well-recognized online resource for type 1 and 2 diabetes, which is extensively referenced.

In 2023, Mark founded Th(is)²Modeling driven by his unwavering commitment to advancing healthcare. Mark`s illustrious career spans over 600 projects in diverse domains such as cardiovascular, pulmonary, diabetes, urology, and oncology. His contributions encompass expert interviews, patient record reviews, extensive modeling (over 250), and meticulous report writing. He has authored over 80 peer-reviewed manuscripts and seen over 225 conference abstracts accepted (see bibliography).

Mark is fluent in Dutch (mother tongue), English, Spanish, and French, and has a solid understanding of German.

Mafalda Ramos brings a wealth of knowledge and experience to our team. With a dual master`s degrees in Biomedical Engineering and Health Economics, she co-founded Th(is)²Modeling solidifying her commitment to advancing healthcare.

Before joining Th(is)²Modeling in November 2023, Mafalda Ramos served as an Associate Principal within IQVIA`s Global Health Economic team. During her 11 years with IQVIA, she delivered global Health Economic modeling studies to a broad set of pharmaceutical and medical devices companies, headquarters and local affiliates. Mafalda`s contributions are extensive, involving the development and adaptation of cost-effectiveness, budget impact models, literature reviews, evidence synthesis, including meticulous collection and analysis of real-world data (RWE) and primary data. She also played a pivotal role crafting HTA (Health Technology Assessment) dossiers, producing technical reports, abstracts, manuscripts, and developing informative posters. Mafalda`s strengths extend to managing projects with intricate complexities across diverse therapeutic areas. Mafalda Ramos was a valued key decision-maker within the Core Diabetes Model Global scientific team. Furthermore, she runs several HEOR and CDM trainings internally and externally.

Mafalda`s proficiency covers a spectrum of Health Economics and Outcomes Research (HEOR) tools, including the Core Diabetes Model (CDM), TreeAge, Excel/VBA, SAS, R, C++, Matlab and Stata.

Her project management experience spans therapeutic areas such as cardiovascular, diabetes, chronic kidney disease, COPD, gastroenterology, burn/skin care, hematology, hospital nutrition, oncology, medical devices, gynecology, labor, ophthalmology, rheumatology, and mental health.

Mafalda`s linguistic versatility is a valuable asset, with Portuguese as her mother tongue and fluency in English and Spanish, she is able to manage and lead geographically diverse projects. Mafalda Ramos is a dedicated and dynamic member of our team, contributing her multifaceted expertise to shape the future of healthcare.

Luís Martins is a dedicated Consultant specializing in C++ programming and he joined Th(is)²Modeling in November 2023. Luís strong foundation in scientific research and a passion for modeling, will continue to support and develop future Disease Models, continuing this way this professional journey initiated at IQVIA.

Before becoming a valued member of our team, Luís worked as an analyst and consultant in IQVIA`s global HEOR team. There, his primary focus was on the scientific and technical advancement of the Core Diabetes Model. Prior to his industry experience at IQVIA, Luís`s career was steeped in scientific exploration, specifically in the field of Engineering Physics and his contributions resulted in multiple peer-reviewed manuscripts within the fields. Luís dedicated approximately two years working as a Research Scientist at the Technological and Nuclear Center, earning his MSc in Engineering Physics from Universidade Nova de Lisboa during that time. In this role, he executed nuclear reaction techniques using the TANDEM particle accelerator and developed a model for the simulation of nuclear reactions technique.

In 2019, Luís achieved a significant milestone by earning his PhD in Engineering Physics from Universidade Nova de Lisboa. His doctoral research predominantly revolved around the development of code for Monte Carlo simulations of X-ray Fluorescence technique.

Luís Martins boasts a versatile skill set encompassing various programming languages and toolkits, including C++, Python, LaBVIEW, and Geant4. As a native Portuguese speaker proficient in English and understanding Spanish, Luís Martins adds to our team`s international diversity and brings a wealth of knowledge and expertise in programming to the forefront of our disease modeling efforts.